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Lilly's Pricing Pattern Eli Lilly has established a pattern with Zepbound that is likely to carry over to retatrutide: High list price ($1,000+/month), consistent with industry norms Competitive direct-to-consumer pricing through LillyDirect, undercutting retail pharmacy costs Savings programs for commercially insured patients Aggressive engagement with Medicare negotiations to secure broad coverage Lilly has been more transparent about consumer pricing than many pharmaceutical companies, and the success of LillyDirect for Zepbound suggests they will use a similar channel for retatrutide

Based on the current stage of clinical development and estimated trial completion dates registered on ClinicalTrials.gov, a realistic earliest possible timeline might be considered as follows: 20252026: Completion of key phase 3 TRIUMPH trial data 20262027: Potential regulatory submission to the MHRA (and FDA/EMA in parallel) 20272028: Possible MHRA marketing authorisation, subject to satisfactory review 2028 onwards: NICE technology appraisal and potential NHS commissioning decision These timelines are speculative and depend on multiple variables, including trial outcomes, the completeness of the regulatory submission, MHRA review timelines, and NICE deliberations

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PSCs are myofibroblast-like cells found in the pancreas, accounting for 47% of total parenchymal cells in the gland